If you want to check out a "pro-as-it-gets" website that features robots, monsters, online comics, sketchbooks and all kinds of EXTREMELY cool design work go here:
Dave Guertin and Greg Baldwin are the owners/artists. they both do all the graphics you see, switching off duties. they are professionals in the gaming industry, and CreatureBox is their personal 'property'.
an artist can learn a lot about how to present and produce their own product by tooling around their site, and seeing how they do it.
The artwork is drawn and inked in Sketchbook Pro, using 21" Cintiqs, then colored in Photoshop, as I understand it.
be sure to check out their timelapse videos that show the art production process under the Gallery link.
I have their second sketchbook set which is extremely cool.
in my opinion, this is how it's done.